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团队简介
Team Introduction
张立兵，教授，理学院化学系，于2014年在中国科学院长春应用化学研究所电分析国家重点实验室获得博士学位，随后在美国亚利桑那州立大学和加拿大多伦多大学做博士后研究，2019年10加入到天津大学理学院化学系，主要研究领域主要为电分析化学及生物传感，纳米生物探针的设计与研发等方面的研究工作，在Nat. Commun., Angew. Chem. Int. Ed., J. Am.Chem. Soc., Nano Lett., Adv. Mater., ACS Nano, Nano Today, Chem. Sci.和Anal. Chem.等国际著名学术期刊上发表SCI论文36篇，论文引用2400余次，H-index为24，曾获中国科学院院长优秀奖等奖项。
本研究组聚焦于高性能生物分子（DNA、蛋白）及杂化功能材料的构建及应用：
1. 电分析化学及生物传感；
2. 生物模板纳米材料的可控制备及生物应用；
3. 多功能纳米材料自组装体系在纳米生物医学应用；
4. 高效生物识别界面的构建及用于细胞粘附及分化研究。
1. 天津大学北洋学者英才计划启动经费，主持，100万
2. 国家自然基金青年基金，主持，26万
3. 国家自然基金重大项目，参与，批准号：21190042
4. 国家自然基金青年基金，参与，批准号：21105094
代表性成果：
(1) Libing Zhang, Zongjie Wang, Jagotamoy Das, Mahmoud Labib, SharifAhmed, Edward H. Sargent, Shana O. Kelley*, Potential-Responsive Surfaces forManipulation of Cell Adhesion, Release, and Differentiation. Angew. Chem. Int. Ed., 2019, 58, 14519-14523.
(2) Libing Zhang, Sae Rin Jean, Xiyan Li, SharifAhmed, Gordon Chan, Jagotamoy Das, Alexandre Zaragoza, Edward H. Sargent, Shana O. Kelley*, Programmable Metal/Semiconductor Nanostructures formRNA-Modulated Molecular Delivery. Nano Lett., 2018, 18,6222-6228.
(3) Libing Zhang, Sae Rin Jean, SharifAhmed, Peter M. Aldridge, Xiyan Li, Fengjia Fan, Edward H. Sargent* and ShanaO. Kelley*, Multifunctional QuantumDot-DNA Hydrogels. Nat. Commun., 2017, 8, 381.
(4) Libing Zhang, Jinbo Zhu, Shaojun Guo,Tao Li, Jing Li, Erkang Wang*, Photoinduced Electron Transfer of DNA/Ag Nanoclusters Modulated byG-Quadruplex/Hemin Complex for the Construction of Versatile Biosensors. J. Am.Chem. Soc. 2013, 135, 2403-2406.
(5) Libing Zhang, Erkang Wang*, MetalNanoclusters: New Fluorescent Probes for Sensors and Bioimaging. Nano Today 2014, 9, 132-157.
(6) Libing Zhang, Jinbo Zhu, Zhixue Zhou, ShaojunGuo, Jing Li, Shaojun Dong, and Erkang Wang*, A New Approach to Light up DNA/Ag Nanoclusters-based Beaconfor Bioanalysis. Chem. Sci., 2013,4, 4004-4010.
(7) ZongjieWang#, Libing Zhang#, Mahmoud Labib,Haijie Chen, Mingyang Wei, Mahla Poudineh, Brenda J. Green, Bill Duong, JagotamoyDas, Sharif Ahmed, Edward H. Sargent, Shana O. Kelley*, Peptide-Functionalized NanostructuredMicroarchitectures Enable Rapid Mechanotransductive Differentiation. ACSAppl. Mater. Interfaces, 2019, 11,41030
(8) Libing Zhang, Shaojun Guo, Jinbo Zhu,Zhixue Zhou, Tao Li, Jing Li, Shaojun Dong, Erkang Wang*, Engineering DNA Three-way Junction withMultifunctional Moieties: SensingPlatform for Bioanalysis. Anal. Chem., 2015, 87, 11295–11300.
(9) Libing Zhang, Jinbo Zhu, Jun Ai, ZhixueZhou, Xiaofang Jia, Erkang Wang*, Label-free G-quadruplex-specific fluorescentprobe for sensitive detection of copper(II) ion. Biosens. Bioelectron., 2013, 39, 268–273.
(10) Libing Zhang,† Shuojun Guo,† Shaojun Dong, Erkang Wang*, Pd nanowires as new biosensing materials for magnifiedfluorescent detection of nucleic acid. Anal.Chem., 2012, 84, 8568–8573.
(11) Libing Zhang, Jinbo Zhu, Tao Li, Erkang Wang*, BifunctionalColorimetric Oligonucleotide Probe Based on a G-quadruplex DNAzyme MolecularBeacon. Anal. Chem., 2011, 83, 8871–8876.
(12) Libing Zhang, Bingyan Han, TaoLi, Erkang Wang*, Label-free DNAzyme-basedfluorescing molecular switch for sensitive and selective detection of lead ion. Chem. Commun., 2011, 47, 3099–3101.
(13) Libing Zhang, Tao Li, BinglingLi, Jing Li, Erkang Wang*, Carbonnanotube–DNA hybrid fluorescent sensor for sensitive and selective detection ofmercury(II) ion. Chem. Commun.,2010, 46, 1476–1478.
(14) Libing Zhang, Hui Wei, Jing Li,Tao Li, Dan Li, Yunhui Li, Erkang Wang*, A carbon nanotubes based ATPapta-sensing platform and its application in cellular assay. Biosens.Bioelectron., 2010, 25, 1897–1901.
(15) Libing Zhang, Jing Li, YuanhongXu, Yueming Zhai, Yunhui Li, Erkang Wang*. Solid-state electrochemiluminescencesensor based on the Nafion/poly(sodium4-styrene sulfonate) composite film. Talanta, 2009, 79, 454-459.
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