导师团队
电能细胞合成生物学及生物制药团队
浏览量:3173   转发量:3

联系方式

Contact Information

  • 所属院系:化工学院
  • 所属专业: 生物与医药
  • 邮箱 : hsong@tju.edu.cn
  • 工作电话 : -

团队简介

Team Introduction

电能细胞合成生物学及生物制药团队


        本团队由宋浩教授领衔,曹英秀(副教授)和李锋(助理教授)两位青年教师组成。

    (实验室在天津大学化工学院的网站:http://chemeng.tju.edu.cn/cn/szdw?type=detail&id=110

        负责人宋浩教授简介:

  1.             入选国家“万人计划”科技创新领军人才,科技部创新人才推进计划“中青年科技创新领军人才”,国家青年特聘专家,
  2.             天津市“合成生物学”创新团体负责人,中国生物工程学会合成生物学专业委员会副主任,
  3.             教育部“合成生物学前沿科学中心”副主任,科技部合成生物学重点研发专项“电能细胞合成生物学”:首席科学家。

        

        教育经历:

            The University of Houston (US): Department of Chemical & Biomolecular Engineering, Ph.D. in Chemical Engineering,  2004

            南开大学:化学系,1994年, 化学本科

        工作经历:

            天津大学:化工学院,教授、博士生导师,2013年-至今

            Nanyang Technological University (Singapore): 2009-2013, School of Chemical & Biomedical Engineering, Assistant Professor

            Duke University (US): Research Associate (Synthetic Biology),  2006-2009

            The University of Texas Medical School (US): Postdoc (Systems & Computational Neurobiology), 2004-2006


1010101010


团队研究方向:

1、电能细胞,半导体合成生物学、光电遗传学,及其在化工生产、能源与环境中的产业化应用

团队针对我国能源、环境、医药化工品合成等领域的重大战略需求,围绕电能细胞“电能-化学能”双向转化核心瓶颈,解析电能细胞跨膜电子传递机制,阐明还原力、能量-物质代谢的协同互作机理,提出高效产电与噬电人工电能细胞的设计原理,构建高效产电、电驱动高附加值化学品定向合成的人工细胞工厂,加速电能细胞工厂在化学品与医药品生产、能源与环境中的产业化应用进程。

 2、生物制药

团队重点关注生物制药问题,以合成生物学、代谢工程的理论和方法,设计构建微生物细胞工厂进行药物的高效生物合成,及酶催化不对称药物的生物转化。聚焦产品:维生素、甜味剂、甾体药物、糖尿病治疗药物、抗菌抗病毒药物、单克隆抗体等医药品和营养品,及其产业化放大和生产。


  • 研究方向Research Directions
合成生物学,电能细胞,光电遗传学,生物制药,能源与环境生物技术,微生物细胞工厂,半导体合成生物学
2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。
科研项目

        团队承担科技部“合成生物学”重点研发专项、重大863项目、973子课题、国家基金委、国家海洋局、以及多项大型制药公司项目10多项,累计主持承担科研经费共计8500多万元。其中,代表性项目包括:

    1、国家重点研发专项(科技部):电能细胞合成生物学(首席科学家)

    2、国家高技术研究发展计划(科技部“863”计划):能源与医药产品模块化设计合成

    3、国家自然科学基金:希瓦氏菌电子传递途径改造实现

    4、国家自然科学基金:还原力动态调控分配驱动的智能微生物电合成系统设计构建

    5、科技部“973” 计划项目子课题:微生物多细胞体系的设计与合成

    6、国家海洋局:高效微生物采油技术和装备开发及产业化示范

    7、国家青年特聘专家:合成生物学

    8、大型企业合作研发:包括中化健康、赤峰制药、扬州联澳制药等



研究成果

      团队在《Nature Chemcial Biology》、《Nature Communication》、《Energy & Environmental Science》、《Angewandte Chemie》、《Nano Energy》、《ACS Catalysis》、《Metabolic Engineering》、《ACS Synthetic Biology》、《Chemical Society Reviews》等高水平期刊发表论文130多篇,申请专利30多项。相关成果获科技部、人民日报、科技日报、新华日报、新华网、CCTVNews、人民网、路透社等网站媒体报道。

图片1222

代表性论文:

Feng Li#, Yuanxiu Li#, Ying-Xiu Cao, Lei Wang, Chen-Guang Liu, Liang Shi, Hao Song*, “Modular engineering to increase intracellular NAD(H/+) promotes rate of extracellular electron transfer of Shewanella oneidensis”, Nature Communications, (2018) 9:3637.  DOI: 10.1038/s41467-018-05995-8.

Lixia Fang, Jie Fan, Congya Wang, Yingxiu Cao* and Hao Song*, “Systematic and genome-wide targets identification to engineer Escherichia coli for high-titer production of free fatty acids”,  Nature Communications, 2021, 12:4976. DOI: https://doi.org/10.1038/s41467-021-25243-w

Hao Song, S. Payne, M. Gray, Lingchong You*. “Spatiotemporal modulation of biodiversity in a synthetic chemical-mediated ecosystem”, Nature Chemical Biology, 5, 929–935 (2009).

Yue Liu, Mingzhu Ding, Wei Ling, Yun Yang, Xiao Zhou, Bingzhi Li, Tao Chen, Yong Nie, Miaoxiao Wang, Boxuan Zeng, Xia Liwi, Hong Liu, Baode Sun, Heming Xu, Jiamei zhang, Yi Jiao, Yanan Hou, Hui Yang, Sijia Xiao, Qucheng Lin, Xinzi He, Wenjie Liao, Zeqi Jin, Yufei Xie, Bofeng Zhang, Tianyu Li, Xi Lu, Jiabei Li, Fan Zhang, Hao Song*, Yingjin Yuan*. “A three-species microbial consortium for power generation”, Energy & Environmental Science, 2017, 10, 1600--1609. 

Tong Lin, Wenqi Ding, Liming Sun, Lei Wang, Chen-Guang Liu, Hao Song*, “Engineered Shewanella oneidensis-reduced graphene oxide biohybrid with enhanced biosynthesis and transport of flavins enabled a highest bioelectricity output in microbial fuel cells”, Nano Energy, 50 (2018) 639–648.

Tong Lin#, Xue Bai#, Yun Yang, Jingyu Wang, Yidan Hu, Bingzhi Li, Ying-Jin Yuan, Hao Song*, “Synthetic Saccharomyces cerevisiae-Shewanella oneidensis consortium enables glucose-fed microbial fuel cell”, AIChE Journal,2017, 63(6):1830-1838.

Yang-Chun Yong, Yang-Yang Yu, Xinhai Zhang, Hao Song*. “Highly Active Bidirectional Electron Transfer by a Self-Assembled Electroactive Reduced-Graphene-Oxide-Hybridized Biofilm", Angewandte Chemie International Edition, 53, 4480-4483 (2014).

Hao Song, Ming-Zhu Ding, Xiao-Qiang Jia, Qian Ma, Ying-Jin Yuan*. "Synthetic microbial consortia: from systematic analysis to construction and applications", Chemical Society Reviews, 43, 6954-6981 (2014).

Chen Xiaoli#, Cao Yingxiu#, Li Feng#, Tian Yao, Hao Song*, “Enzyme-Assisted Microbial Electrosynthesis of Poly(3-hydroxybutyrate) via CO2 Bioreduction by Engineered Ralstonia eutropha”, ACS Catalysis, 2018, 8, 4429-4437.

Yingxiu Cao#, Xiaofei Li#, Feng Li, Hao Song*, “CRISPRi-sRNA: transcriptional-translational regulation of extracellular electron transfer of Shewanella oneidensis“, ACS Synthetic Biology, DOI: 10.1021/acssynbio.6b00374, 2017.

Feng Li; Yuanxiu Li; Liming Sun; Xiaofei Li; Changji Yin; Xingjuan An; Xiaoli Chen; Yao Tian; Hao Song*, “Engineering Shewanella oneidensis enables Xylose-fed Microbial Fuel Cell”, Biotechnology for Biofuels, 2017, 10: 196.

Yang-Chun Yong#, Xiao-Cheng Dong#, Mary B. Chan-Park, Hao Song*, Peng Chen*. “Macroporous and monolithic anode based on polyaniline hybridized three-dimensional graphene for high-performance microbial fuel cells”, ACS Nano, 6 (3), 2394–2400 (2012).

Yun Yang, Yichao Wu, Yidan Hu, Yingxiu Cao, Poh Chueh Loo, Cao Bin*, Hao Song*. “Engineering electrode-attached microbial consortia for high-performance xylose-fed microbial fuel cell”, ACS Catalysis, 5 (11), 6937–6945 (2015).

Yun Yang, Yuanzhao Ding, Yidan Hu, Bin Cao, Scott A. Rice, Staffan Kjelleberg, Hao Song*. "Enhancing bidirectional electron transfer of Shewanella oneidensis by a synthetic flavin pathway", ACS Synthetic Biology, 4 (7), 815–823 (2015).

Ting Liu, Yang-yang Yu, Xiao-peng Deng, Chun Kiat Ng, Bin Cao, Jing-Yuan Wang, Scott Rice, Staffan Kjelleberg, Hao Song*. "Enhanced Shewanella biofilm promotes bioelectricity generation", Biotechnology & Bioengineering, 112, 2051–2059 (2015). 

Yidan Hu, Yun Yang, Evgeny Katz, Hao Song*. "Programming Quorum Sensing-based AND Gate in Shewanella oneidensis for logic gated-Microbial Fuel Cells”, Chemical Communications, 51, 4184-4187 (2015).

Shaomei Yang, Yingxiu Cao, Liming Sun, Congfa Li, Xue Lin, Zhigang Cai, Guoyin Zhang, Hao Song*, “Modular pathway engineering of Bacillus subtilis to promote de novo biosynthesis of menaquinone-7”, ACS Synthetic Biology, 2019, 8(1), 70-81. 

Shaomei Yang, Yong-Ping Wang, Zhigang Cai, Guoyin Zhang, Hao Song*, “Metabolic Engineering of Bacillus subtilis for High-Titer Production of Menaquinone-7”, AIChE Journal, 2020: 66:e16754.


近期文章

2021年

Lixia Fang, Jie Fan, Congya Wang, Yingxiu Cao* and Hao Song*, “Systematic and genome-wide targets identification to engineer Escherichia coli for high-titer production of free fatty acids”,  Nature Communications, 2021, 12:4976. 

Nan Yang, Yao Tian, Mai Zhang, Feng Li, Xiting Peng, Jianxun Li, Yi Li, Bei Fan, Fengzhong Wang*, and Hao Song*, “Photocatalyst-Enzyme Hybrid Systems for Light-Driven Biotransformation”, Biotechnology Advances, in press

Hong Sun, Jingli Yang, Kun He, Yong-Ping Wang, Hao Song*, “Enhancing production of 9a-hydroxy-androst-4-ene-3,17-dione (9-OHAD) from phytosterols by metabolic pathway engineering of mycobacteria”, Chemical Engineering Science, 2021, 230, 116195.

Xue Bai#, Tong Lin#, Nan Liang, Bing-Zhi Li, Hao Song*, Ying-Jin Yuan*, “Engineering synthetic microbial consortium to efficiently convert glucose and xylose co-substrates into electricity power”, Biochemical Engineering Journal,2021, 172, 108052.

Zhenyang Wang#, Wenbin Liu#, Wei Liu, Yuanyuan Ma*, Yatong Li, Baoqi Wang, Xiaozhen Wei, Zhiming Liu, Hao Song*, “Co-immobilized recombinant glycosyltransferases efficiently convert Rebaudioside A to M in cascade”, RSC Advances, 2021, 11, 15785 - 15794.

Yao Tian#, Yongchao Zong#, Yinuo Zhou, Jiansheng Li, Nan Yang, Mai Zhang, Zhiqi Guo, and Hao Song*, “Thiophene-Conjugated Porous C3N4 Nanosheets for Boosted Photocatalytic Nicotinamide Cofactors Regeneration to Facilitate Solar-to-Chemical Enzymatic Reactions”,Transactions of Tianjin University, 2021, 27, 42–54, 

Junqi Zhang#, Zheng Chen#, Changjiang Liu#, Jianxun Li, Xingjuan An, Deguang Wu, Xi Sun, Longping Fu, Feng Li*, Hao Song*, “Construction of an acetate metabolic pathway to enhance electron generation of engineered Shewanella oneidensis”, Frontiers in Bioengineering and Biotechnology, in press

Yaru Chen, Lixia Fang, Xiang Ying, Meijie Cheng, Lin Wang, Panxing Sun, Zhaoyu Zhang, Yingxiu Cao*, & Hao Song*, “Development of genome-level, highly efficient, comprehensive base editing toolbox to promote extracellular electron transfer in Shewanella oneidensis MR-1”, submitted

Tong Lin#, Wenqi Ding#, Yun Yang, Derek R. Lovley, and Hao Song*, “Exogenous cytochrome OmcS from Geobacter and flavins biosynthesis enormously boost bidirectional electron transfer efficiency in Shewanella oneidensis”,  submitted

杨楠,田瑶,张劢,郭之旗,宋浩*,“生物光电化学电池复合系统:光电驱动生物转化”,《科学通报》, in press

赵贞尧#,张保财#,李锋*,宋浩*,“产电细胞的合成生物学设计构建”,《化工学报》 2021, 72 (1): 468-482.

丁倩,曹英秀,李锋,林童,陈媛媛,陈正,宋浩*,““共轭聚合物-产电菌”复合生物电极构建及其在微生物燃料电池中的应用”,《生物工程学报》, 2021, 37(1): 1−14.

刘向#,张君奇#,张保财, 杨池, 李锋*,宋浩*, “强化产电微生物与电极间电子传递速率的研究进展”,《生物工程学报》, 2021, 37(2): 361−377.

Juntao Zhao+, Feng Li+, Yingxiu Cao, Xinbo Zhang, Tao Chen, Hao Song, Zhiwen Wang*, “Microbial extracellular electron transfer and strategies for engineering electroactive microorganisms”, Biotechnology Advances, 2021, DOI:10.1016/j.biotechadv.2020.10768

Ziyu Li, Weiwei Chang, Tianyu Cui, Dake Xu, Dawei Zhang*, Yuntian Lou, Hongchang Qian, Hao Song, Arjan Mol, Fahe Cao, Tingyue Gu & Xiaogang Li, “Adaptive bidirectional extracellular electron transfer during accelerated microbiologically influenced corrosion of stainless steel”, Communications Materials. (2021) 2:67. https://doi.org/10.1038/s43246-021-00173-8.


2020年

Shaomei Yang, Yong-Ping Wang, Zhigang Cai, Guoyin Zhang, Hao Song*, “Metabolic Engineering of Bacillus subtilis for High-Titer Production of Menaquinone-7”, AIChE Journal, 2020: 66:e16754.

Jinhua Zhang, Yanshu Zhao, Yingxiu Cao, Zhenpeng Yu, Guoping Wang, Yiqun Li, Xiaoqiong Ye, Congfa Li, Xue Lin, Hao Song*, “Synthetic sRNA-based engineering of Escherichia coli for enhanced production of full-length immunoglobulin G”, Biotechnology Journal, 2020, 15, 1900363.

Jinhua Zhang, Yanshu Zhao, Yingxiu Cao, Zhenpeng Yu, Guoping Wang, Yiqun Li, Xiaoqiong Ye, Congfa Li, Xue Lin, and Hao Song*, “sRNA-Based Screening Chromosomal Gene Targets and Modular Designing Escherichia coli for High-Titer Production of Aglycosylated Immunoglobulin G”, ACS Synthetic Biology(in press)

Sun, Hong#, Jingli Yang, Jingli#, Lin, Xue; Li, Congfa; He, Yongjin; Cai, Zhigang; Zhang, Guoyin; Song, Hao*, “de novo high-titer production of delta-tocotrienol in recombinant Saccharomyces cerevisiae”, Journal of Agriculture and Food Chemistry(in press)

Jiansheng Li#, Yao Tian#, Yinuo Zhou, Yongchao Zong, Nan Yang, Mai Zhang, Zhiqi Guo, Hao Song*, “Abiotic-Biological Hybrid Systems for CO2 Conversion to Value-Added Chemicals and Fuels“, Transactions of Tianjin University (in press)

Hong Sun孙鸿, Jingli Yang, Hao Song*, “Engineering mycobacteria artificial promoters and ribosomal binding sites for enhanced sterol production”, Biochemical Engineering Journal 修回

Yao Tian#, Yinuo Zhou#, Yongchao Zong, Jiansheng Li, Nan Yang, Mai Zhang, Zhiqi Guo, Hao Song*, “Construction of Functionally Compartmental Inorganic Photocatalyst-Enzyme System via Imitating Chloroplast for Efficient Photoreduction of CO2 to Formic Acid”, ACS Applied Materials and Interfaces 修回

Huan Yu#, Ziying Gong#, Junqi Zhang, Li Feng*, Hao Song*, “Bidirectional electron transfer-driven chemicals biosynthesis”, Systems and Synthetic Biology (Honorable Guest Editors Tianwei Tan, Haijia Su and Guest Editor Yongqin Lv) 返修

Jiansheng Li#, Yao Tian#, Yinuo Zhou, Yongchao Zong, Nan Yang, Mai Zhang, Zhiqi Guo, Hao Song*, “Abiotic-Biological Hybrid Systems for CO2 Conversion to Value-Added Chemicals and Fuels“, Transactions of Tianjin University (in press)

Yao Tian#, Yongchao Zong#, Yinuo Zhou, Jiansheng Li, Nan Yang, Mai Zhang, Zhiqi Guo, and Hao Song*, “Thiophene-Conjugated Porous C3N4 Nanosheets for Boosted Photocatalytic Nicotinamide Cofactors Regeneration to Facilitate Solar-to-Chemical Enzymatic Reactions”, Transactions of Tianjin University (in press)

Bo‐Yu Geng, Lian‐Ying Cao, Feng Li, Hao Song, Chen‐Guang Liu*, Xin‐Qing Zhao and Feng‐Wu Bai, “Potential of Zymomonas mobilis as an electricity producer in ethanol production”, Biotechnology for Biofuels, 2020, 13: 36.

赵妍淑#,张金华#,宋浩*,“工程原核生物和酵母菌中生产单克隆抗体和抗体片段的研究进展”, 《中国生物工程杂志》(in press)

徐静, 由紫暄,张君奇,吴德光, 李锋*,宋浩*,“合成生物学改造电活性生物膜的研究进展”, 《化工学报》(李春教授邀稿)(in press)

陈媛媛#,张保财#,李锋*,宋浩*,“产电微生物的筛选方法研究进展”,《生物工程学报》(in press)

丁倩,曹英秀,李锋,林童,陈媛媛,陈正,宋浩*,““共轭聚合物-产电菌”复合生物电极构建及其在微生物燃料电池中的应用”,《生物工程学报》(in press)

周一诺#,杨楠#,田瑶, 宗永超, 李建圣, 张劢, 郭之旗, 宋浩*,“基于辅酶的光驱动酶催化体系”,《科学通报》(in press)

刘向#,张君奇#,吴德光,李锋*,宋浩*, “强化电能细胞-电极界面作用的研究进展”,《生物工程学报》(in press)


2019年

Shaomei Yang, Yingxiu Cao, Liming Sun, Congfa Li, Xue Lin, Zhigang Cai, Guoyin Zhang, Hao Song*, “Modular pathway engineering of Bacillus subtilis to promote de novo biosynthesis of menaquinone-7”, ACS Synthetic Biology, 2019, 8(1), 70-81. 

Ying-Xiu Cao, Meng-yuan Song, Congfa Li, Xue Lin, Hao Song*,”Development of Synthetic Gene Toolkit of Shewanella oneidensis MR-1”, Frontiers in Microbiology, March 2019 | Volume 10 | Article 410. (doi: 10.3389/fmicb.2019.00410)

Feng Li#, Xingjuan An#, Deguang Wu, Jing Xu, Yuanyuan Chen, Wenchao Li, Yingxiu Cao, Xuewu Guo, Xue Lin, Congfa Li, Sixin Liu, Hao Song*, “Engineering microbial consortia for high-performance cellulosic hydrolyzates-fed microbial fuel cells”, Frontiers in Microbiology, March 2019 | Volume 10 | Article 409. (doi: 10.3389/fmicb.2019.00409)

Ziyin Zhang, Feng Li, Yingxiu Cao, Hong Sun, Yao Tian, Zhenpeng Yu, Guoping Wang, Yiqun Li, Xiaoqiong Ye, Hao Song*,“Electricity-driven P450 Enzyme-catalyzed 7α-hydroxylation of steroid in engineered yeast”, Catalysis Science & Technology,  2019,9,4877–4887.  (Journal Front Cover)

Jialin Meng#, Yao Tian#, Xiaohui Wu, Yinuo Zhou, Jiansheng Li, Nan Yang,Yongchao Zong, and Hao Song*, “Thiophene-Modified Doubleshell Hollow g-C3N4 Nanosphere Boosts NADH Regeneration via Synergistic Enhancement of Charge Excitation and Separation”, Catalysis Science & Technology, 2019, 9, 1911 - 1921.

Cong-Ya Wang#, Ying-Xiu Cao#, Yong-Ping Wang, Li-Ming Sun, Hao Song*, “CRISPRi to systematically identify crucial genes in amino acids metabolism for enhanced surfactin biosynthesis in engineered Bacillus subtilis”,Microbial Cell Factories, (2019) 18:90.

Mingzhu Ding, Biqiang Chen, Xiaojun Ji, Jingwen Zhou, Huiyuan Wang, Xiwei Tian, Xudong Feng, Hua Yue, Yongjin Zhou, Hailong Wang, Jianping Wu, Pengpeng Yang, Yu Jiang, Xuming Mao, Gang Xiao, Cheng Zhong, Wenhai Xiao, Bingzhi Li, Lei Qin, Jingsheng Cheng, Mingdong Yao, Ying Wang, Hong Liu, Lin Zhang, Linling Yu, Tao Chen, Xiaoyan Dong, Xiaoqiang Jia, Songping Zhang, Yanfeng Liu, Yong Chen, Kequan Chen, Jinglan Wu, Chenjie Zhu, Wei Zhuang, Sheng Xu, Pengfei Jiao, Lei Zhang, Hao Song, Sheng Yang, Yan Xiong, Yongquan Li, Youming Zhang, Yingping Zhuang, Haijia Su, Weiping Fu, Yingming Huang, Chun Li, Zongbao K. Zhao, Yan Sun, Guo-Qiang Chen, Xueming Zhao, He Huang, Yuguo Zheng, Lirong Yang, Zhiguo Su, Guanghui Ma, Hanjie Ying, Jian Chen,Tianwei Tan and Yingjin Yuan*, “Biochemical engineering in China”, Reviews in Chemical Engineering, 2019. DOI: https://doi.org/10.1515/revce-2017-0035

Xueting He#, Tingli Xue#, Yuanyuan Ma*, Junyan Zhang, Zhiquan Wang, Jiefang Hong, Lanfeng Hui, Jianjun Qiao, Hao Song and Minhua Zhang, “Identification of functional butanol-tolerant genes from Escherichia coli mutants derived from error-prone PCR-based whole genome shuffling”, Biotechnology for Biofuels, 2019, 12:73.

Cong‑Cong Jin#, Jin‑Lai Zhang#, Hao Song, and Ying‑Xiu Cao* “Boosting the biosynthesis of betulinic acid and related triterpenoids in Yarrowia lipolytica via multimodular metabolic engineering”, Microbial Cell Factories, (2019) 18:77.


2018年

Feng Li#, Yuanxiu Li#, Ying-Xiu Cao, Lei Wang, Chen-Guang Liu, Liang Shi, Hao Song*, “Modular engineering to increase intracellular NAD(H/+) promotes rate of extracellular electron transfer of Shewanella oneidensis”, Nature Communications, (2018) 9:3637.  DOI: 10.1038/s41467-018-05995-8.

Tong Lin, Wenqi Ding, Liming Sun, Lei Wang, Chen-Guang Liu, Hao Song*, “Engineered Shewanella oneidensis-reduced graphene oxide biohybrid with enhanced biosynthesis and transport of flavins enabled a highest bioelectricity output in microbial fuel cells”, Nano Energy, 50 (2018) 639–648.

Chen Xiaoli#, Cao Yingxiu#, Li Feng#, Tian Yao, Hao Song*, “Enzyme-Assisted Microbial Electrosynthesis of Poly(3-hydroxybutyrate) via CO2 Bioreduction by Engineered Ralstonia eutropha”, ACS Catalysis, 2018, 8, 4429-4437.

Li, Feng#; Li, Yuanxiu#; Sun, Li-ming; Chen, Xiaoli; An, Xingjuan; Yin, Changji ; Cao, Yingxiu; Wu, Hui; Song, Hao*. “Modular engineering intracellular NADH regeneration boosts extracellular electron transfer of Shewanella oneidensis MR-1”, ACS Synthetic Biology, 2018. 7(3): 885–895.

Feng Li, Lei Wang, Chenguang Liu, Deguang Wu, Hao Song*,”Engineering exoelectrogens by synthetic biology strategies”, Current Opinion in Electrochemistry, 2018, 10: 37-45.

Shiqin Yu#, Bin Lai#, Manuel R. Plan, Mark P. Hodson, Endah A. Lestari, Hao Song, Jens O. Krömer*, “Improved performance of Pseudomonas putida in a bioelectrochemical system through overexpression of periplasmic glucose dehydrogenase”, Biotechnology and Bioengineering, 2018, 115(1):145-155.

Yang-Yang Yu, Zhen Fang, Lu Gao, Hao Song, Liang Yang, Baodong Mao, Weidong Shi, Yang-Chun Yong*,“Engineering of bacterial electrochemical activity with global regulator manipulation”, Electrochemistry Communications, 2018, 86: 117–120.

Kun He, Hong Sun, Hao Song*, “Engineering phytosterol transport system in Mycobacterium sp. strain MS136 enhances production of 9α-hydroxy-4-androstene-3,17-dione”, Biotechnology Letters, 2018, 40(4), 673-678.

Suzhen Huang, Tingli Xue, Zhiquan Wang, Yuanyuan Ma*, Xueting He, Jiefang Hong, Shaolan Zou, Hao Song*, Minhua Zhang, “Furfural-tolerant Zymomonas mobilis derived from error-prone PCR-based whole genome shuffling and their tolerant mechanism”, Applied Microbiology and Biotechnology, 2018, 102 (7): 3337-3347.

Yuan Yu, Pengcheng Chang, Huan Yu, Huiyong Ren, Danning Hong, Zeyan Li, Ying Wang, Hao Song, Yixin Huo*, Chun Li*, “Productive Amyrin Synthases for Efficient α-Amyrin Synthesis in Engineered Saccharomyces cerevisiae”, ACS Synthetic Biology, 2018, 7 (10), pp 2391–2402.


2017年

Yue Liu, Mingzhu Ding, Wei Ling, Yun Yang, Xiao Zhou, Bingzhi Li, Tao Chen, Yong Nie, Miaoxiao Wang, Boxuan Zeng, Xia Liwi, Hong Liu, Baode Sun, Heming Xu, Jiamei zhang, Yi Jiao, Yanan Hou, Hui Yang, Sijia Xiao, Qucheng Lin, Xinzi He, Wenjie Liao, Zeqi Jin, Yufei Xie, Bofeng Zhang, Tianyu Li, Xi Lu, Jiabei Li, Fan Zhang, Hao Song*, Yingjin Yuan*. “A three-species microbial consortium for power generation”, Energy & Environmental Science, 2017, 10, 1600-1609.   (Journal Back Cover)

Yingxiu Cao#, Xiaofei Li#, Feng Li, Hao Song*, “CRISPRi-sRNA: transcriptional-translational regulation of extracellular electron transfer of Shewanella oneidensis“, ACS Synthetic Biology, 2017, 6 (9) :1679. 

Feng Li, Yuanxiu Li, Liming Sun, Xiaofei Li, Changji Yin, Xingjuan An, Xiaoli Chen, Yao Tian, Hao Song*, “Engineering Shewanella oneidensis enables Xylose-fed Microbial Fuel Cell”, Biotechnology for Biofuels, 2017, 10: 196.

Tong Lin#, Xue Bai#, Yun Yang, Jingyu Wang, Yidan Hu, Bingzhi Li, Ying-Jin Yuan, Hao Song*, “Synthetic Saccharomyces cerevisiae-Shewanella oneidensis consortium enables glucose-fed microbial fuel cell”, AIChE Journal,2017, 63(6):1830-1838.

Feng Li#, Changji Yin#, Yuanxiu Li, Xuewu Guo, Hao Song* , “Synthetic Klebsiella pneumoniae-Shewanella oneidensisconsortium enables glycerol-fed high-performance microbial fuel cells”, Biotechnology Journal, 2017, in press

Yiyuan Wang#, Yingxiu Cao#, Yuanxiu Li, Jiayu Jin, Jinliang Li, Hao Song*,“Asymmetric biosynthesis of intermediates of anti-HIV drugs: A recent progress”, Tetrahedron: Asymmetry, 2017, 28: 745-757.


2016年

Tran Chien Dang, Yuan Yin, Yangyang Yu, Dinh-Tuan Phan, Chun Yang, Bin Cao*, Hao Song*, Yuejun Kang*, “A Membrane-free Microfluidic Microbial Fuel Cell for Rapid Characterization of Exoelectrogenic Bacteria”, Microfluidics and Nanofluidics, (2016) 20: 144.

Ting Liu, Yang-yang Yu, Dongzhe Li, Hao Song, Xiaoli Yan, Wei Ning Chen*. “The effect of external resistance on biofilm formation and internal resistance in Shewanella inoculated microbial fuel cells”, RSC Advances, 2016, 6, 20317-20323.


2015年

Yun Yang, Yichao Wu, Yidan Hu, Yingxiu Cao, Poh Chueh Loo, Cao Bin*, Hao Song*. “Synthetic bacterial consortium for high-performance microbial fuel cell using xylose as carbon source”, ACS Catalysis, 2015, 5 (11), pp 6937–6945.

Yun Yang, Yuanzhao Ding, Yidan Hu, Bin Cao, Scott A. Rice, Staffan Kjelleberg, Hao Song*. "Enhancing bidirectional electron transfer of Shewanella oneidensis by a synthetic flavin pathway", ACS Synthetic Biology, 4 (7), 815–823 (2015).

Ting Liu, Yang-yang Yu, Xiao-peng Deng, Chun Kiat Ng, Bin Cao, Jing-Yuan Wang, Scott Rice, Staffan Kjelleberg, Hao Song*. "Enhanced Shewanella biofilm promotes bioelectricity generation", Biotechnology & Bioengineering, 112, 2051–2059 (2015). Highlighted in the Journal’s Spotlight feature.

Yidan Hu, Yun Yang, Evgeny Katz, Hao Song*. "Programming Quorum Sensing-based AND Gate in Shewanella oneidensis for logic gated-Microbial Fuel Cells”, Chemical Communications, 51, 4184-4187 (2015).

Yangchun Yong*, Xiang-Yang Wu, Jian-Zhong Sun, Ying-Xiu Cao, Hao Song*. "Engineering quorum sensing signaling of Pseudomonas for enhanced wastewater treatment and electricity harvest: A review", Chemosphere, 140, 18–25 (2015).

Yu Yangyang, Guo Chunxian, Yong Yangchun, Li Changming, Hao Song*. "Nitrogen doped carbon nanoparticles enhanced extracellular electron transfer for high-performance microbial fuel cells anode",  Chemosphere, 140, 26–33 (2015).

Ming-Hua Shen, Hao Song, Bing-Zhi Li*, Ying-Jin Yuan. “Deletion of d-ribulose-5-phosphate 3-epimerase (RPE1) induces simultaneous utilization of xylose and glucose in xylose-utilizing Saccharomyces cerevisiae”, Biotechnology Letters, 37(5), 1031-1036 (2015).


2014年

Hao Song, Ming-Zhu Ding, Xiao-Qiang Jia, Qian Ma, Ying-Jin Yuan*. "Synthetic microbial consortia: from systematic analysis to construction and applications", Chemical Society Reviews, 43, 6954-6981 (2014).

Yang-Chun Yong, Yang-Yang Yu, Xinhai Zhang, Hao Song*. “Highly Active Bidirectional Electron Transfer by a Self-Assembled Electroactive Reduced-Graphene-Oxide-Hybridized Biofilm", Angewandte Chemie International Edition, 53, 4480-4483 (2014).

Robert Smith, Cheemeng Tan, K. Riccione, Anand Pai, Hao Song, Lingchong You*. “Programmed Allee effect in bacteria causes a tradeoff between population spread and survival”, Proceedings of National Academy of Sciences USA (PNAS), 111 (5), 1969-1974 (2014).

Huiqing Chong, Hefang Geng,Hongfang Zhang, Hao Song, Lei Huang, Rongrong Jiang*. "Enhancing E. coli isobutanol tolerance through engineering its global transcription factor cAMP receptor protein (CRP)", Biotechnology & Bioengineering, 111(4): 700–708 (2014).

Jian Zha, Ming-Hua Shen, Meng-Long Hu, Hao Song, Ying-Jin Yuan*. “Enhanced expression of genes involved in initial xylose metabolism and the oxidative pentose phosphate pathway in the improved xylose-utilizing Saccharomyces cerevisiae through evolutionary engineering”, Journal of Industrial Microbiology & Biotechnology, 41(1):27-39 (2014).

Qian Ma, Yang Zou, Ya-jin Lv, Hao Song, Ying-Jin Yuan*. “Comparative Proteomic Analysis of Experimental Evolution of the Bacillus cereus-Ketogulonicigenium vulgare Co-Culture”, PLOS One, 9(3): e91789 (2014). 

Mingzhu Ding, Zou Yang, Hao Song, Ying-Jin Yuan*. "Metabolomic Analysis of Cooperative Adaptation between Co-Cultured Bacillus cereus and Ketogulonicigenium vulgare", PLOS One, 9(4): e94889 (2014). 




学生信息
当前位置:教师主页 > 学生信息
入学日期
所学专业
学号
学位
招生信息
当前位置:教师主页 > 招生信息
招生学院
招生专业
研究方向
招生人数
推免人数
考试方式
招生类别
招生年份

天津大学研究生院招生办公室

文件上传中...

分享
回到
首页
回到
顶部