实验室现有教授2名，副教授4名，讲师2名，工程师1名。

        实验室坚持严谨治学、求实创新的教育理念，鼓励个性化及学术、性格、创新上的“张力”，营造了温馨、和谐、奋进、创新的文化氛围。实验室先后获得天津大学金牌活力实验室，天津大学劳动示范先进集体等荣誉称号。

横向项目：

“猪繁殖与呼吸综合征病毒GP5/2酵母表达菌的构建”；

“禽戊肝酵母表达菌的构建”；

“口服新冠COVID-19 病毒保护性抗原S蛋白酵母表面展示菌株疫苗技术的工程化”;

。

（1）免疫生物学 

新型免疫标志分子的挖掘及功能；先天性免疫分子调控回路的设计及重塑; 受体靶向生物天然及仍佐剂设计及其调控机制；免疫分子的高通量表达鉴定及筛选技术。

（2) 微生物合成生物学

• 益生菌设计、工程化建造、代谢调控机制及健康重塑机制；
• 资源微生物基因组大尺度改造重建技术；
• 基于酵母、噬菌体、乳酸菌的口服黏膜疫苗研发平台技术；
•  预测疫苗学及新型疫苗的设计与智造技术
• 动物病原抗体库的工程化构建、高通量筛选及应用开发技术。

（3）病原致病及免疫机理研究

病毒快速拯救技术；病原感染的修饰组学； 病原逃逸先天性免疫机制；微生物大尺度改造重建技术；人工免疫分子的体外高通量表达鉴定和筛选技术。

        先后获省部级科技进步一、二、三等奖4项，厅局级科技进步一等奖3项，二等奖1项，完成国家成果登记2项。主、参编著作8部，获得国家发明专利等7项，申报中专利6项。近3年发表的部分论文：

2021年

2020年

1. Peidian Shi,Yanyu Guo, Yanxin Su, Min Zhu, Yali Fu, Heng Chi, Jiaqi Wu,Jinhai Huang*，SUMOylation of DDX39A alters binding & export ofantiviraltranscripts to control innate immunity. The Journal of Immunology, 2020, ji2000053. doi:10.4049/jimmunol.2000053. 

2. Yanyu Guo,Ruiqiao Li, Zheng Tan, Jingxuan Shi,Yali Fu, Yinna Song, Min Zhu, Lei Zhang, Jinhai Huang*，E3 ubiquitin ligase ASB8 negativelyregulatesinterferon via regulating TBK1/IKKi homeostasis. Molecular Immunology. 2020, 121,195-203.

3. Yali Fu,Dong Lu,· Yanxin Su,, Heng Chi, Jiashun Wang, Jinhai Huang*，Vif Protein of Caprine Arthritis Encephalitis Virus Inhibits Interferon Production, Archives of Virology. 2020,165（7）：1557-1567.

4. Xiao Xiao,Wentao Zhang, Deping Hua,Lilin Zhang, Wei Meng, Jinhai Huang*, Lei Zhang*, Cold-inducibleRNA-binding protein (CIRBP) promotes porcine reproductive and respiratory syndromevirus (PRRSV)-induced inflammatory response. International Immunopharmacology. Vol 86, 2020, 106728.

5. Shufen Wu, Xiaochan Wang, Yuxin Bao, Chuanying Zhang, Huanhuan Liu, Zhenjing Li, Mianhua Chen, Changlu Wang, Qingbin Guo, Xin Peng*, Molecular insight on the binding of monascin to bovine serum albumin (BSA) and its effect on  antioxidant characteristics of monascin. Food Chemistry. 2020, 315：126228.

6.  Jiaqi Wu, HengChi,Yanyu Guo, Aiping Cao, Jingxuan Shi, Min Zhu, Lilin Zhang, Deping Hua*,Jinhai Huang*, Antiviral Protein Viperin Modulate N protein to InhibitPorcine Epidemic Diarrhea Virus proliferation. Archives of Virology, 2020

7.  Chen Chen#,Deping Hua#, Jingxuan Shi, Zheng Tan, Min Zhu, Kun Tan, Lilin Zhang, JinhaiHuang*，Porcine immunoglobulin Fc fused P30/P54 protein of African swine fevervirus displaying on surface of S. cerevisiae elicit strong antibody productionin swine. Virologica Sinica,2020 .

2019年

1. RuiqiaoLi#, ChenChen#, Jing He, Lilin Zhang, Lei Zhang, Yanyu Guo, Jinhai Huang*, E3 Ligase ASB8 Promotes PRRSV Proliferation and Function via Stabilizing of Nsp 1α and Degrading of IKK. Virology, 2019, 532 : 55–68.

2. PeidianShi #,Yanxin Su#, Ruiqiao Li, Lei Zhang, Lilin Zhang, Chen Chen, KayFaaberg, Jinhai Huang*，Dual regulation of nuclear/plasma distribution and modification of TRAIP by porcine reproductive and respiratorysyndrome virus nonstructural protein 1α promotes viral proliferation. Frontiers in Immunology, 2019, 9:1-18.

3. Jia Kong, Meimei Wang, Shuangyi He, Xin Peng*, Xiaohong Qin*, Structural characterization and directed modification of Sus scrofa SAMHD1 reveal the mechanism underlying deoxynucleotide regulation. FEBS Journal, 2019, 286:3844-3857.

4. Chengxue Zhao, ChenChen, Ying Li, Shuren Dong, Kun Tan,,Yuhui Tian,,Lilin Zhang, Jinhai Huang, LeiZhang*, Genomic characterization of a novel recombinant porcine astrovirusisolated in northeastern China. Archives of Virology, 2019, 164(3): 1469-1473.

5. Peidian Shi1#, YanxinSu1#, Ruiqiao Li1, Zhixuan Liang, Shuren Dong Jinhai Huang*，PEDV nsp16 negatively regulates innate immunity topromote viral proliferation. Virus Research, 2019, 265，57–66.

2018年

1. PeidianShi,Yanxin Su, Yi Li, Lilin Zhang, Dong Lu, Ruiqiao Li, Lei Zhang, Jinhai Huang*，The Alternatively Spliced Porcine FcγRI Regulated PRRSV-ADE Infection and Proinflammatory Cytokine Production. Developmental and Comparative Immunology, 2018, 90:186–198. 

2. Peidian Shi#,Lilin Zhang#, Jiashun Wang#,Dong Lu, Yi Li, Menglu Shen, Jie Ren, Lei Zhang*, Jinhai Huang*, The porcine FcεRI mediated the PRRSV multiplicationand regulatedinflammatory reaction. Virologica Sinica, 2018, 33:249-260.

3. YanxinSu#, Peidian Shi#, Lilin Zhang#, Dong Lu, Chengxue Zhao, Ruiqiao Li, Lei Zhang, and Jinhai Huang*. The Superimposed Deubiquitination Effect of OTULIN and PRRSV Nsp11 Promoted the Multiplication of PRRSV. Journal of Virology, 2018, 92(9): e00175-18. 

4. Lei Zhang, Jie Ren, Peidian Shi, Dong Lu, Chengxue Zhao,Yanxin Su, Lilin Zhang, Jinhai Huang*,   Theimmunological regulation roles of porcine β-1, 4 galactosyltransferase V (B4GALT5) in PRRSV Infection. Frontiers in cellular and infection microbiology. 2018, 8(3):1-13.

5. Pei Chen, Lei Zhang, Na Chang, Peidian Shi, Tian Gao, Lilin Zhang, Jinhai Huang*, Preparationof virus-like particles for porcine circovirus type 2 by YeastFab Assembly. Virus Genes. 2018，54:246–255. 

6. Wenjiao Hong, Lilin Zhang, Pei Chen, Songbao Dai, Yihe Xia, Jinhai Huang*, Lei Zhang*,  Staphylococcal Enterotoxins Modulated the Porcine Toll-Like Recep­tor Transcription and Medicated Inflammatory Response. Archives on Veterinary Science and Technology, 2018, (1):1-15. 

7. Na Chang, Shunyu Yao, Deguang Chen, Lei Zhang, Jinhai Huang, Lilin Zhang*，The Hog1 positiveregulated YCT1 gene expression undercadmium tolerance of budding yeast，FEMS Microbiology Letters, 365, 2018, 365（17）：1-10.

2017年

1. RuiqiaoLi, Xuefeng Qi, Xueying Han, Caihong Liu, Jing Wang, RuichunWang, Jingyu Wang*, Jinhai Huang*, Deteriorationof eggshell quality is related to calbindin in laying hens infected with velogenic genotype VIId Newcastle diseasevirus. Theriogenology. 2017, 91(3):62-68.

2. YiLi, Hui Deng, Pei-Dian Shi, Dan-Dan Xu, LiLin Zhang, Lei Zhang*, Jinhai Huang* , Toxic effects of seuare different from those of other staphylococcal enterotoxins. American Journal of Translational Research.2017, 9(4):1618-1629.

3. Jiashun Wang#, Yi Li1#, Hui Deng, Jia Chen, Ying Li, Zhixuan Liang, Deping Hua, Jinhai Huang*. Rapid detection of food-borne Salmonellacontamination using IMBs-qPCR method based on pagC gene. Brazilian Journal of Microbiology, 2017.10:3241-9.

4. Menglu Shen, Yi Li, LinlinZhang, Songbao Dai, Jiashun Wang, Yongqing Li, Lei Zhang*, Jinhai Huang*，Staphylococcalenterotoxin Profile of China Isolates and the Superantigenicity of Some Novel Enterotoxins，Archives of Microbiology. 2017, 199: 1-14. 

5. RuiqiaoLi,† Lilin Zhang,† Peidian Shi, Hui Deng, Yi Li, Jie Ren, Xubin Fu, Lei Zhang*aand Jinhai Huang，ImmunologicalEffects of Different Types of Synthetic CpG Oligodeoxynucleotides on Porcine Cells. RSC advances. 2017, 7, 43289-99.

       已培养研究生50余人，其中在国内外著名高校、科研院所工作18人，国内外大中型企业16人，行政单位6人。在读博士4人， 在读研究生18人。

        目前在读博士研究生4名，硕士研究生26名。每年招收硕士研究生15名，博士研究生（含硕博连读）2名。

        本实验室与美国、欧洲、澳洲，国内多所大学和研究机构，企业建立了密切的合作关系，多项合作正在开展之中。多名研究生去美国、以色列、欧洲进行学术交流，优秀博、硕士研究生有机会获得赴美、欧、澳等国家和地区交流培养的机会。

黄金海（教授）：jinhaih@tju.edu.cn

张   蕾（教授）：zhanglei@tju.edu.cn

张丽琳（副教授）：lyliazhang@163.com

彭    鑫（副教授）：pengxin5403@tju.edu.cn

华德平（副教授）：dphua_00@163.com

李泽兴（副研究员）：zexing.li@163.com

郭艳余（讲师）：yanyu.guo@tju.edu.cn

联系电话：022-27403902