聚焦生物制药与合成生物学的世界科技前沿，服务国家生物医药产业的重大需求。

主持完成国家自然科学基金项目、国家重点研发计划项目、天津市自然科学基金、广东省重点领域项目。

现主持国家重点研发计划项目、天津市项目。

[1] Zhu Y, Yan X, Li W, Qiao J, Zhao G-R*. Cofactor-coupled cytochrome P450 engineering enables high-level biosynthesis of asiatic acid in Saccharomyces cerevisiae. Bioresource Technology, 2026, 441:133558. 

[2] Zhu Y, Yan X, Li W, Qiao J, Zhao GR*. Modular Metabolic Engineering of Saccharomyces cerevisiae for Enhanced Production of Ursolic Acid. J Agric Food Chem. 2025 Feb 12;73(6):3580-3590.

[3] Tian D, Qin Z, Liu W, Caiyin Q, Li W*, Zhao GR*, Qiao J*.Engineering a biosensor based high-throughput screening platform for high-yield caffeic acid production in Escherichia coli. Metab Eng. 2026, 93:128-144.

[4] Tian D, Tian G, Qin Z, Wang S, Wu S, Zhang P, Xiong B, Ge M, Lu J, Li W*,Zhao GR*, Qiao J*. Engineering of Escherichia coli cytoplasm and periplasm for efficient synthesis of salvianic acid A. Metab Eng. 2025, 91:415-429. 

[5] QiuZ, Han Y, Li J, Ren Y, Liu X, Li S*, Zhao GR*, Du L*. Metabolic division engineeringof Escherichia coli consortia for de novo biosynthesis of flavonoids andflavonoid glycosides. Metab Eng. 2025, 11;89:60-75.

[6] Li J, Wang L, Zhang N, Cheng S, Wu Y*, Zhao G-R*. Enzyme and Pathway Engineering for Improved Betanin Production in Saccharomyces cerevisiae. ACS Synth Biol. 2024,13(6):1916-1924.

[7] LiuX, Li L,ZhaoG-R*. Systems Metabolic Engineering of Escherichia coli Coculturefor De Novo Production of Genistein. ACS Synthetic Biology, 2022,11(5):1746-1757.

[8] Qiu Z,Liu X, Li J, Qiao B, Zhao G-R*. Metabolic Division in an Escherichia coli Coculture System for Efficient Production of Kaempferide. ACS Synth Biol. 2022, 11(3):1213-1227.

[9] Lei D, Qiu Z, Wu J, Qiao B, QiaoJ, Zhao GR*. Combining metabolic and monoterpene synthase engineering for de novoproduction of monoterpene alcohols in Escherichia coli. ACS Synthetic Biology,2021, 10(6):1531-1544.

[10] LiuZ, Lei D, Qiao B, Li S, Qiao J, Zhao G-R*. Integrative Biosynthetic Gene Cluster Mining to Optimize a Metabolic Pathway to Efficiently Produce L-Homophenylalanine in Escherichia coli. ACS Synth Biol. 2020, 9(11):2943-2954.

[11] Wu J, Cheng S, Cao J, Qiao J, Zhao G-R*. Systematic optimization of limonene production in engineered Escherichia coli. J Agric Food Chem, 2019, 67(25):7087-7097.

[12] Cheng S, Liu X, Jiang G, Wu J, Zhang J-L, Lei D, Yuan Y-J, Qiao J, Zhao G-R*. Orthogonal engineering of biosynthetic pathway for efficient production of limonene in Saccharomyces cerevisiae. ACS Synth Biol, 2019, 8(5):968-975.

[13] Liu X, Li X-B, Jiang J, Liu Z-N, Qiao B, Li F-F, Cheng J-S, Sun X, Yuan Y-J, Qiao J*,  Zhao G-R*. Convergent engineering of syntrophic Escherichia coli coculture for efficient production of glycosides. Metab Eng, 2018,47:243-253.

[14] Zhou L, Ding Q, Jiang G-Z,Liu Z-N, Wang H-Y, Zhao G-R*. Chromosome engineering of Escherichia coli for constitutive production of salvianic acid A. Microb Cell Fact, 2017,16:84.

[15] Yao Y-F,Wang C-S,Qiao J,Zhao G-R*.Metabolic engineering of Escherichia coli for production of salvianic acid Avia an artificial biosynthetic pathway. Metab Eng, 2013, 19: 79-87.

[16] Fu ZH, Ma Y, Cheng S, Zhong Y, Wang N, Ba Z, Zhao G-R*, Wu Y*. Synthetic rewriting of the IGH locus. Cell genomics, 18 May 2026, 101252.

[17] Fu ZH, He SZ, Wu Y*, Zhao GR*. Design and deep learning of synthetic B-cell-specific promoters. Nucleic Acids Res. 2023, 51(21):11967-11979. 

[18] Fu ZH, Cheng S, Li JW, Zhang N, Wu Y*, Zhao GR*. Synthetic tunable promoters for flexible control of multi-gene expression in mammalian cells. J Adv Res. 2025, 78：351-361.