主要针对人类疾病的早期诊断和治疗，开发基于核酸扩增检测、光致发光生物传感检测的体内外诊断新策略。自主研发针对预防和治疗肿瘤、感染性疾病、炎症、神经退行性疾病的各种新型智能药物递送与响应的生物材料。欢迎感兴趣的同学报考，特别是拥有化学、材料、生物、医学等相关背景的学生。

本小组关于材料合成、疾病诊断和治疗方向发表了诸如Advanced Materials, ACSNano, Biomaterials, Biosensors and Bioelectronics, Analytical Chemistry等30余篇本领域的国际顶级期刊SCI论文，累计影响因子近300，单篇IF＞10的6篇。申请国内外发明专利100余项。多项研究成果受到美国、新加坡、日本等众多机构和媒体的引用报道。目前在研的课题有国自然面上项目、青年项目、天津市重点项目等。

刘哲   教授

邮箱：zheliu@tju.edu.cn                                                                                                              

主要研究方向：

1. 医学分子探针与新型药物缓控释递送方法；

2. 影像辅助诊疗与可视化医学。

3. 超声辅助BBB开放与脑部给药的诊疗一体化策略及无创治疗方法；

4.浅表恶性肿瘤（乳腺癌、黑色素瘤、鼻咽癌等）的诊疗新策略；

发表SCI论文：

[1]  Liu Zhe*, Chen Waner, Li Yihong, Xu Qien. Integrin αvβ3-targeted C-dot Nanocomposites as MultifunctionalAgents for Cell Targeting and Photoacoustic Imaging of Superficial MalignantTumors, Analytical Chemistry, 2016, 8811955-11962.

[2]  Liu Zhe, Lammers Twan, Ehling Josef, Fokong Stanley, Bornemann Jorgen, Kiessling Fabian, Gätjens Jessica. Iron Oxide Nanoparticle-Containing Microbubbles as Contrast Agents for MR and Ultrasound Dual-Modality Imaging, Biomaterials, 2011, 32(26), 6155-6163.

[3]  Liu Zhe*, Xu Qien, Li Yihong, Chen Waner. Fluorescent C-dot Nanocomposites as Efficient PhotothermalAgents and Multi-modal Imaging Tracers, Materials Chemistry Frontiers, 2017, 1, 538-541.

[4]  Li Yihong, Song Yuanhui, Xu Qien，Liu Zhe*. Hybrid Polymeric Nanoprobes for Folate Receptor-TargetedPhotoacoustic Imaging In Vivo, Materials Chemistry Frontiers, 2017, 1, 916-921.

[5]  Liu Zhe*, Doleschel Dennis, Koczera Patrick, Kiessling Fabian, Gätjens Jessica. Versatile synthesis for PBCA-based hybrid fluorescent microbubbles and their potential theranostic applications to cell-labelling and imaging, Chem. Commun., 2012, 48(42), 5142-5144.

[6]  Chen Waner, Yang Yan, Shangguan Dihua, Wu Yuejing, Liu Zhe*. Multifunctional hard-shelled microbubbles for differentiating imaging, cavitation and drug release by ultrasound, RSC Advances, 2017, 7, 25892-25896.

[7]  Liu Zhe*, Shi Changcan, Li Yihong, Song Yuanhui, Xu Qien. Fluorescent genipin cross-linked REDV-conjugated polymeric microbubbles for human vascular endothelial cell (HVEC) targeting, RSC Advances, 2016, 6(39), 32710-32714.

[8]  Zou Chunpeng, Wu Beibei, Dong Yanyan, Song Zhangwei, Zhao Yaping, Ni Xianwei, Yang Yan, Liu Zhe*. Biomedical Photoacoustics: Fundamentals, Instrumentation and Perspectives on Nanomedicine, International Journal of Nanomedicine, 2016, 12, 179-195.

[9]  Song Yuanhui, Li Yihong, Xu Qien, Liu Zhe*. Mesoporous Silica Nanoparticles for Stimuli-ResponsiveControlled Drug Delivery: Advances, Challenges and Outlook, International Journal of Nanomedicine, 2016, 12, 87-110.

郑斌   副教授  

邮箱：binzheng@tju.edu.cn

主要研究方向：

1. 研制各种基于工程化的无害病毒/细菌等智能仿生材料用于神经相关疾病的诊断与治疗；

2. 探索多功能荧光材料在微创纳米光遗传学中的应用；

3. 针对呼吸道病毒的新型鼻腔喷雾纳米疫苗研制；

4. 用组合化学构建适合干细胞体内外定向分化为神经细胞的生物界面材料；

5. 基于光、声、电、磁等物理效应的体内药物/基因缓控释技术的开发与应用探索。

发表SCI论文：

1.Bin Zheng, Lin Su, Xiaoqun Gong, Hanjie Wang, Jin Chang. Advanced Materials. 2016, 28, 707–714. DOI: 10.1002/adma.201503961. (一区, IF: 25.809)

2.Bin Zheng, Hanjie Wang, Huizhuo Pan, Jin Chang. ACS Nano. 2017;11(12):11898-11907. ACS Nano. 2017;11:11898-11907. DOI: 10.1021/acsnano.（一区, IF: 13.903)

3.Bin Zheng, Hongbin Chen, Xiaoqun Gong, Hanjie Wang, Jin Chang. ACS Applied Materials & Interfaces, 2016, 8, 21603–21611. DOI: 10.1021/acsami.6b07642. (一区,  IF: 8.456)

4.Bin Zheng, Yang Bai, Hanjie Wang and Jin Chang. ACS Applied Materials & Interfaces, 2018, DOI:10.1021/acsami.8b05706. (一区,  IF: 8.456)

5.Bin Zheng, Xiaoqun Gong, Hanjie Wang, Jin Chang. Nanomedicine: Nanotechnology, Biology, and Medicine, 2016, 12, 472-473. DOI: https://doi.org/10.1016/j.nano.2015.12.079 (一区, IF:6.5)

6.Bin Zheng, Jingya Wang, Huizhuo Pan, et al. Journal of Colloid and Interface Science, 2017, 506:460-470. DOI: 10.1016/j.jcis.2017.07.077. (二区, IF: 6.361)

7.Bin Zheng, Yang Bai, Hanjie Wang, Jin Chang, et al. Biomaterials Science, 2018, DOI: 10.1039/C8BM00218E. (二区, IF: 5.831)

8.Bin Zheng, Xiaoqun Gong, Hanjie Wang, Jin Chang. Nanotechnology, 2015, 26, 425102. DOI: 10.1088/0957-4484/26/42/425102. (二区,  IF: 3. 573)

9.Beibei Hou,#·Bin Zheng,#·Xiaoqun Gong, et al. Journal of Materials Chemistry B, 2015,3,3531-3540. DOI: 10.1039/c5tb00240k (一区, 共同一作，IF:4.872)

10.Beibei Hou,#Bin Zheng,# Xiaoqun Gong, Hanjie Wang, Journal of Colloid & Interface Science, 2017,494, 363-372. DOI: 10.1016/j.jcis.2017.01.053. (二区, 共同一作，IF:6.361)

11.Hongbin Chen,# Bin Zheng,# Xiaoqun Gong, Hanjie Wang, Jin Chang. Materials Science & Engineering C, 2017, 79, 372-381. DOI: 10.1016/j.msec.2017.05.053. (二区, 共同一作，IF:5.08)

12.Fang Zhou,#Bin Zheng,# Ying Zhang, Hanjie Wang, Jin Chang. Nanotechnology. 2016, 27, 23560.1. DOI: 10.1088/0957-4484/27/23/235601.（二区, 共同一作，IF:3.573）

13.Wei Qin,#Bin Zheng,# Yuan Yuan, Hanjie Wang, Jin Chang, Yonglan Wang. European Journal Of Oral Sciences. 2016, 124,334-342. DOI: 10.1111/eos. (三区, 共同一作，IF:1.655)

14.Chunhong Dong，Zhongyun Liu，Sheng Wang, Bin Zheng, Weisheng Guo，Weitao Yang，Xiaoqun Gong，Xiaoli Wu，Hanjie Wang，Jin Chang. ACS Applied Materials & Interfaces, 2016, 8, 32688–32698. DOI: 10.1021/acsami.6b11803. (一区, IF: 8.456)

15.Beibei Hou,Weitao Yang, Chunhong Dong, Bin Zheng, Ying Zhang, JingWu, HanjieWang, Jin Chang. Materials Science & Engineering C Materials for Biological Applications, 2017, 74:94-102. DOI: 10.1016/j.msec.2017.02.016. (二区, IF: 5.080)

16.Huiquan Wang, Pengfei Hua, Yu Zheng, Zhe Zhao, Bin Zheng, Jin Chang,Hanjie Wang，Jin-hai Wang. Materials Science & Engineering C. 2017, 80:102-109. DOI: 10.1016/j.msec.2017.05.131. (二区,  IF: 5.080)

赵飞   副教授

邮箱：feizhao@tju.edu.cn

主要研究方向：

1.核酸扩增检测诊断

2.阿尔兹海默症的早期诊断；

3.荧光材料研制；

4.光致发光生物传感检测。

发表SCI论文：

[1] Fei Zhao, Bonhan Koo, Huifang Liu, Choong Eun Jin, Yong Shin*. A single-tube approach for in vitro diagnostics using diatomaceous earth and optical sensor. Biosensors and Bioelectronics, 99, (2018) 443-449.

[2] Fei Zhao, Eun Yeong Lee, Yong Shin*. Improved Reversible Cross-linking-based Solid-phase RNA Extraction for Pathogen Diagnostics, Analytical Chemistry, 90, (2018), 1725-1733.

[3] Huifang Liu, Fei Zhao, Choong Eun Jin, Bonhan Koo, Eun Yeong Lee, Linlin Zhong, Kyusik Yun, Yong Shin*. Large Instrument- and Detergent-Free Assay for Ultrasensitive Nucleic Acids Isolation Via Binary Nanomaterial, Analytical Chemistry, 90, (2018) 5108-5115.

[4] Fei Zhao, Jongsung Kim*. Highly Sensitive and Selective Photoluminescence Detection of Copper Ions via In Situ Formation of Fluorescent Polydopamine. Journal of Nanoscience and Nanotechnology, 17, (2017) 5776-5779.

[5] Fei Zhao, Jongsung Kim*. The Effect of Temperature on Photoluminescence Enhancement of Quantum Dots in Brain Slices. Journal of Nanoscience and Nanotechnology, 17, (2017) 2606-2609.

[6] Fei Zhao, Jongsung Kim*. The Preparation of an Optical Hydrogen Peroxide Sensor Using Polydopamine as a Sensing Medium. Journal of Nanoscience and Nanotechnology, 17, (2017) 2291-2295.