课题组负责人

       仰大勇，天津大学讲席教授。国家杰青、国家优青、海外高层次人才计划获得者。

课题组科研团队

诚挚邀请有志青年加入，共探科学之美！

       承担国家科技部重点研发计划2项、国家自然科学基金7项、天津市自然科学基金3项等。部分项目如下：

       1. 国家科技部重点研发项目：高通量脱氧核糖核酸（DNA）合成创新技术及仪器研发

       2. 国家科技部重点研发项目：新一代DNA合成技术

       3. 国家自然科学基金优秀青年项目：生物功能高分子

       4. 国家自然科学基金面上项目：基于超支化DNA靶向聚合的无酶化核酸检测研究

       5. 国家自然科学基金面上项目：聚合物/DNA杂化纳米凝胶的构筑及其作为核酸药物载体的研究

       6. 国家自然科学基金青年项目：基于iPDMS 和SI-ATRP 的静电纺丝表面功能化研究

       7. 国家自然科学基金青年项目：手性碳量子点的绿色合成及其对DNA构象和功能的调控研究

       8. 国家自然科学基金青年项目：DNA-稀土发光纳米粒子复合水凝胶的合成及其在肿瘤区域化疗中的应用

       9. 天津市自然科学基金青年项目：含碲高分子/DNA杂化水凝胶的构筑及作为细胞三维培养基质的研究

       10. 天津市自然科学基金青年项目： 上转换发光DNA凝胶用于脑胶质瘤区域化疗及实时监测

        在Proc. Natl. Acad. Sci. U.S.A.、Nat. Commun.、Nat. Protoc.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Adv. Mater.、Chem. Rev.、Prog. Polym. Sci.、Acc. Chem. Res.、Acc. Mater. Res.、Nano Today、Nano Lett.、Biomaterials和Adv. Funct. Mater. 等国际顶级期刊发表学术论文100余篇。

代表性论文:

1) Jianpu Tang+, Xuemei Jia+, Qian Li+ , Zhen Cui , Aiqi Liang , Bin Ke , Dayong Yang*, Chi Yao*, A DNA-based hydrogel for exosome separation and biomedical applications. Proceedings of the National Academy of Sciences of the United States of America, 2023, 120, e2303822120.

2) Nachuan Song, Yiwen Chu, Shuai Li, Xiaoting Fan, Jianpu Tang, Hongjin Li, Ruoyu Tao, Fengqin Li, Junru Li, Dayong Yang*, Peifeng Liu*, A Dual-Enzyme-Responsive DNA-Based Nanoframework Enables Controlled Co-Delivery of CRISPR-Cas9 and Antisense Oligodeoxynucleotide for Synergistic Gene Therapy. Advanced Functional Materials, 2023, 2306634.

3) Fengqin Li+, Junru, Li+, Weiqiang Yang+, Shuai Yang, Congshuo Chen, Ling Du, Junyang Mei, Qianyun Tang, Xiaojing Chen, Chi Yao, Dayong Yang*, Xiaolei Zuo*, Peifeng Liu*, Framework-Hotspot Enhanced Trans Cleavage of CRISPR-Cas12a for Clinical Samples Detection. Angewandte Chemie International Edition, 2023, e202305536.

4) Chi Yao+*, Yuwei Xu+, Jianpu Tang+, Pin Hu, Hedong Qi, Dayong Yang*, Dynamic Assembly of DNA-ceria Nanocomplex in Living Cells Generates Artificial Peroxisome. Nature Communications, 2022, 13, 7739.

5) Chi Yao+, Junhan Ou+, Jianpu Tang+, Dayong Yang*, DNA Supramolecular Assembly on Micro/Nanointerfaces for Bioanalysis. Accounts of Chemical Research, 2022, 15, 2043. 

6) Yuhang Dong+, Feng Li+, Zhaoyue Lv, Shuai Li, Meihe Yuan, Nachuan Song, Jinqiao Liu, Dayong Yang*, Lysosome Interference Enabled by Proton-Driven Dynamic Assembly of DNA Nanoframework inside Cells. Angewandte Chemie International Edition, 2022, 61, e202207770. 

7) Feng Li+, Yujie Liu+, Yuhang Dong, Yiwen Chu, Nachuan Song, Dayong Yang*, Dynamic Assembly of DNA Nanostructures in Living Cells for Mitochondrial Interference. Journal of the American Chemical Society, 2022, 144, 4667. 

8) Feng Li+, Nachuan Song+, Yuhang Dong, Shuai Li, Linghui Li, Yujie Liu, Zhemian Li, Dayong Yang*, A Proton-Activatable DNA-Based Nanosystem Enables Co-Delivery of CRISPR/Cas9 and DNAzyme for Combined Gene Therapy. Angewandte Chemie International Edition, 2022, 61, e202116569. 

9) Huaixin Zhao+, Linghui Li+, Feng Li*, Chunxia Liu, Mengxue Huang, Jiao Li, Feng Gao, Xinhua Ruan, Dayong Yang*, An Energy Stored DNA-based Nanocomplex for Laser-free Photodynamic Therapy. Advanced Materials, 2022, 34, 2109920. 

10) Chi Yao+, Hedong Qi+, Xuemei Jia, Yuwei Xu, Zhaobin Tong, Zi Gu, Dayong Yang*, A DNA Nanocomplex Containing Cascade DNAzymes and Promoter-Like Zn-Mn-Ferrite for Combined Gene/Chemo-dynamic Therapy. Angewandte Chemie International Edition, 2022, 61, e202113619. 

11) Jianpu Tang, Junhan Ou, Chenxu Zhu, Chi Yao*, Dayong Yang*, Flash Synthesis of DNA Hydrogel via Supramacromolecular Assembly of DNA Chains and Upconversion Nanoparticles for Cell Engineering. Advanced Functional Materials, 2022, 32, 2107267. 

12) Chi Yao+, Jianpu Tang+, Chenxu Zhu, Sen Yang, Han Tang, Luxi Dong, Chunzhi Zhang, Qianyun Tang, Peifeng Liu*, Dayong Yang*, A Signal Processor Made from DNA Assembly and Upconversion Nanoparticle for Pharmacokinetic Study. Nano Today, 2022, 42, 101352. 

13) Chi Yao, Yuwei Xu, Pin Hu, Junhan Ou, Dayong Yang*, Gene-like Precise Construction of Functional DNA Materials. Accounts of Materials Research, 2022, 3, 42. 

14) Jinpeng Han, Yanfei Guo, Hang Wang, Kunyu Zhang, Dayong Yang*, Sustainable Bioplastic Made from Biomass DNA and Ionomers. Journal of the American Chemical Society, 2021, 143, 19486. 

15) Chi Yao+, Chenxu Zhu+, Jianpu Tang, Junhan Ou, Rui Zhang, Dayong Yang*, T Lymphocyte-captured DNA Network for Localized Immunotherapy. Journal of the American Chemical Society, 2021, 143, 19330. 

16) Chi Yao+, Rui Zhang+, Jianpu Tang, Dayong Yang*, Rolling Circle Amplification (RCA)-based DNA Hydrogel. Nature Protocols, 2021, 16, 5460.

17) Feng Li+, Wenting Yu+, Jiaojiao Zhang, Yuhang Dong, Xiaohui Ding, Xinhua Ruan, Zi Gu, Dayong Yang*, Spatiotemporally Programmable Cascade Hybridization of Hairpin DNA in Polymeric Nanoframework for Precise siRNA Delivery. Nature Communications, 2021, 12, 1138.

18) Feng Li+, Zhaoyue Lv+, Xue Zhang, Yuhang Dong, Xiaohui Ding, Zhemian Li, Shuai Li, Chi Yao, Dayong Yang*, Supramolecular Self-assembled DNA Nanosystem for Synergistic Chemical and Gene Regulations on Cancer cells. Angewandte Chemie International Edition, 2021, 133, 25761. 

19) Jinpeng Han, Yuchen Cui, Zi Gu, Dayong Yang*, Controllable Assembly/Disassembly of Polyphenol-DNA Nanocomplex for Cascade-responsive Drug Release in Cancer cells. Biomaterials, 2021, 273, 120846.

20) Huaixin Zhao+, Zhili Zhang+, Duo Zuo+, Linghui Li, Feng Li*, Dayong Yang*, A Synergistic DNA-polydopamine-MnO2 Nanocomplex for Near-infrared Light Powered DNAzyme-mediated Gene Therapy. Nano Letters, 2021, 21, 5477. 

21) Jinpeng Han, Yuchen Cui, Feng Li, Zi Gu, Dayong Yang*, Responsive Disassembly of Nucleic Acid Nanocomplex in Cells for Precision Medicine. Nano Today, 2021, 39, 101160.

22) Huaixin Zhao+, Jigang Lv+, Feng Li, Zhili Zhang, Chunzhi Zhang, Zi Gu, Dayong Yang*, Enzymatical Biomineralization of DNA Nanoflowers Mediated by Manganese Ions for Tumor Site Activated Magnetic Resonance Imaging. Biomaterials, 2021, 268, 120591. 

23) Chi Yao+, Weijian Wu+, Han Tang, Xuemei Jia, Jianpu Tang, Xinhua Ruan, Feng Li, David Tai Leong, Dan Luo, Dayong Yang*, Self-assembly of Stem Cell Membrane-Camouflaged Nanocomplex for MicroRNA-Mediated Repair of Myocardial Infarction Injury. Biomaterials, 2020, 257, 120256. 

24) Huaixin Zhao+, Huiting Zhao+, Yi Jiao, Yi Zhu, Chunxia Liu, Feng Li, Yinsong Wang, Zi Gu, Dayong Yang*, Biosynthetic Molecular Imaging Probe for Tumor-targeted Dual-modal Fluorescence/magnetic Resonance Imaging. Biomaterials, 2020, 256, 120220. 

25) Yuhang Dong+, Chi Yao+, Yi Zhu, Lu Yang, Dan Luo, and Dayong Yang*, DNA Functional Materials Assembled from Branched DNA: Design, Synthesis and Applications. Chemical Reviews, 2020, 120, 9420. 

26) Chi Yao+, Han Tang+, Weijian Wu, Jianpu Tang, Weiwei Guo, Dan Luo, Dayong Yang*, Double Rolling Circle Amplification Generates Physically Crosslinked DNA Network for Stem Cell Fishing. Journal of the American Chemical Society, 2020, 142, 3422. 

27) Dong Wang, Jinhui Cui, Mingzhe Gan, Zhaohui Xue, Jing Wang, Peifeng Liu, Yue Hu, Yehudah Pardo, Shogo Hamada, Dayong Yang*, Dan Luo*, Transformation of Biomass DNA into Biodegradable Materials from Gels to Plastics for Reducing Petrochemical Consumption. Journal of the American Chemical Society, 2020, 142, 10114. 

28) Xiaocui Guo+, Feng Li+, Chunxia Liu, Yi Zhu, Nannan Xiao, Zi Gu, Dan Luo, Jianhui Jiang, Dayong Yang*, Construction of Organelle-like Architecture by Dynamic DNA Assembly in Living Cells. Angewandte Chemie International Edition, 2020, 59, 20651. 

29) Feng Li+, Shuai Li+, Xiaocui Guo, Yuhang Dong, Chi Yao, Yangping Liu, Yuguang Song, Xiaoli Tan, Lizeng Gao, Dayong Yang*, Chiral Carbon Dots Mimicking Topoisomerase I to Enantioselectively Mediate Topological Rearrangement of Supercoiled DNA Enantioselectively. Angewandte Chemie International Edition, 2020, 59, 11087. 

30) Jianpu Tang+, Chi Yao+, Zi Gu, Sunghwan Jung, Dan Luo, Dayong Yang*, Super-soft and Super-elastic DNA Robot with Magnetically-driven Navigational Locomotion for Cell Delivery in Confined Space. Angewandte Chemie International Edition, 2020, 59, 2490. 

31) Jinpeng Han+, Yuchen Cui+, Xinpeng Han, Chenyu Liang, Wenguang Liu, Dan Luo, Dayong Yang*, Super-soft DNA/Dopamine-grafted-dextran Hydrogel as Dynamic Wire for Electric Circuits Switched by a Microbial Metabolism Process. Advanced Science, 2020, 7, 2000684. 

32) Renkuan Liao, Feng Zhao, Shogo Hamada, Peiling Yang, Huan Xu, Dan Luo*, Dayong Yang*, DNA-based Engineering System for Improving Human and Environmental Health: Identification, Detection, and Treatment. Nano Today, 2020, 35, 100958. 

33) Huaixin Zhao+, Chunxia Liu+, Zi Gu, Luxi Dong, Feng Li, Chi Yao, Dayong Yang*, Persistent Luminescent Nanoparticles Containing Hydrogel for Targeted, Sustained and Autofluorescence-free Tumor Metastasis Imaging. Nano Letters, 2020, 20, 252. 

34) Xiaocui Guo+, Feng Li+, Lihui Bai, Wenting Yu, Xue Zhang, Yi Zhu, Dayong Yang*, Gene Circuit Compartment on Nanointerface Facilitatating Cascade Gene Expression. Journal of the American Chemical Society, 2019, 141, 19171. 

35) Feng Li+, Jianpu Tang+, Jinhui Geng, Dan Luo, Dayong Yang*, Polymeric DNA Hydrogel: Design, Synthesis and Applications. Progress in Polymer Science, 2019, 98, 101163. 

36) Jinpeng Han, Likun Xiong, Xingyu Jiang, Xiaoyan Yuan*, Yong Zhao*, Dayong Yang*, Bio-functional Electrospun Nanomaterials: from Topology Design to Biological Applications. Progress in Polymer Science, 2019, 91, 1. 

37) Huaixin Zhao+*, Gang Shu+, Jinye Zhu, Yanyan Fu, Zi Gu, Dayong Yang*, Persistent Luminescent Metal-Organic Frameworks with Long-Lasting Near Infrared Emission for Tumor Site Activated Imaging and Drug Delivery. Biomaterials, 2019, 217, 119332. 

38) Ke Meng+, Chi Yao+, Qianmin Ma, Zhaohui Xue, Yaping Du, Wenguang Liu, Dayong Yang*, A Reversibly Responsive Fluorochromic Hydrogel Based on Lanthanide-mannose Complex. Advanced Science, 2019, 6, 1802112. 

招生方向和专业

报考专业：生物化工、生物化学与分子生物学、食品科学、生物与医药

招生方向：化学、化工、生物、药学、高分子及相关专业

招生方式：推荐免试、普通招考

联系方式

姚池老师：chi.yao@tju.edu.cn

导师团平台：http://tj.teacher.360eol.com/teacherBasic/preview?teacherId=2960

课题组主页：http://yanglab-dna.com

微信公众号：仰大勇课题组